Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria?

Performance of serology assays for diagnosing celiac disease in a clinical setting.

Diagnosis of celiac disease frequently depends upon serology assays. We set out to prospectively assess the diagnostic value of five serology tests: an enzyme-linked immunosorbent assay (ELISA) for tissue transglutaminase (tTG)-immunoglobulin A (IgA) and tTG-IgG, a chemiluminescence assay for tTG-IgA, an ELISA for deamidated gliadin peptide (DGP) IgG and IgA screening, and detection of endomysi...

Another step towards celiac screening.

In 1888, Samuel Gee described a disorder of chronic maldigestion and malabsorption that affected individuals of all ages, particularly children 1 to 5 years of age, that he termed, “coeliac affection.” Although he did not know the exact cause, he aptly suspected that the treatment was some form of dietary restriction, with a reduced allowance of “farinaceous foods,” rich in starch or flour. Mor...

Screening for celiac disease.

DANS CE NUMÉRO, le Dr Ernest G. Seidman et des collègues présentent un compte rendu sur une étude de dépistage de l’anticorps de l’antigliadine sérique pour détecter la maladie coeliaque chez les enfants. Dans cet éditorial, les auteurs soutiennent que la mise en service de tels tests constitue un progrès important, étant donné surtout que l’on est très loin de diagnostiquer suffisamment la mal...

Diagnosing Celiac Disease: Role of the Pathologists

Duodenal biopsy is an essential component in the diagnosis of celiac disease (CD). Although the classical findings of increased number of intraepithelial lymphocytes, crypt hyperplasia and villous atrophy are very characteristic, the diagnosis cannot be achieved on the basis of histopathology alone, as there are many entities that can mimic CD and a close collaboration of a pathologist and a cl...

Wanted: diagnostic criteria for adult celiac disease.